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Key Points The sculpting of neuronal connections during brain development depends on a precise balance between inhibition and excitation an excess of GABA (-aminobutyric acid)-mediated inhibition might prevent growth or synapse formation, whereas an excess of glutamatergic excitation could lead to toxicity

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The hypotheses on the pathogenesis of Alzheimers disease include cholinergic hypothesis, amyloid toxicity hypothesis, oxidative stress hypothesis, etc

It impacts how fat is made (lipogenesis) and how fat is broken down (lipolysis)

Since only partial information is available for each class, analyzing microarray experiments represents a valuable approach ahead of targeted expression studies